Authored by two longtime researchers in tobacco science, the book examines the isolation and characterization of each component. It explores developments in pertinent analytical technology and results of experimental studies on biological activity, toxicity, and tumorigenicity, including the inhibition of adverse biological activity of specific tobacco smoke component by another tobacco smoke component. The authors discuss the controversies over the extrapolation of the biological effect of a specific component administered individually by one route versus its biological effect when the component is in a highly complex mixture and is administered by a different route. They also cite studies in which cigarette design technologies were developed to control the per cigarette mainstream smoke yield of Federal Trade Commission-defined tar and one or more specific tobacco smoke components of concern.