Peptide and Protein Design for Biopharmaceutical Applications - ISBN:0470319615

Peptide and Protein Design for Biopharmaceutical Applications

Date: 23 May 2011, 03:01

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Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create вЂtailor-made' peptides and proteins with improved pharmacological properties.
Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include:
Computer modeling of peptides and proteins
Peptidomimetics
Design and synthesis of cyclic peptides
Carbohydrates in peptide and protein design
De novo design of peptides and proteins
Medical development applications
An extended case study - the design of insulin variants
Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

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