Inhibitors of Protein Kinases and Protein Phosphates - ISBN:3540212426

Inhibitors of Protein Kinases and Protein Phosphates

Date: 13 April 2011, 10:18

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Nearly all aspects of cell life (and death) are controlled by the phosphorylation of proteins, which is catalysed by protein kinases (PKs) and reversed by protein phosphatases (PPs). The role of PKs can be likened to that of interpreters, who translate stimuli and signals into biochemical events. For this reason, PKs and PPs are themselves interlinked and highly regulated, forming complex communicative networks. Not surprisingly, therefore, the deregulation of PKs results in cell malfunction, eventually resulting in neoplastic growth and other diseases.

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