Making Sense of Life: Explaining Biological Development with Models, Metaphors, and Machines | Date: 28 April 2011, 06:35
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Making Sense of Life: Explaining Biological Development with Models, Metaphors, and Machines
By Evelyn Fox Keller
* Publisher: Harvard University Press
* Number Of Pages: 400
* Publication Date: 2003-10-31
* ISBN-10 / ASIN: 067401250X
* ISBN-13 / EAN: 9780674012509
Product Description:
What do biologists want? If, unlike their counterparts in physics, biologists are generally wary of a grand, overarching theory, at what kinds of explanation do biologists aim? How will we know when we have "made sense" of life? Such questions, Evelyn Fox Keller suggests, offer no simple answers. Explanations in the biological sciences are typically provisional and partial, judged by criteria as heterogeneous as their subject matter. It is Keller's aim in this bold and challenging book to account for this epistemological diversity--particularly in the discipline of developmental biology.
In particular, Keller asks, what counts as an "explanation" of biological development in individual organisms? Her inquiry ranges from physical and mathematical models to more familiar explanatory metaphors to the dramatic contributions of recent technological developments, especially in imaging, recombinant DNA, and computer modeling and simulations.
A history of the diverse and changing nature of biological explanation in a particularly charged field, Making Sense of Life draws our attention to the temporal, disciplinary, and cultural components of what biologists mean, and what they understand, when they propose to explain life.
(20020510)
Summary: Clear, interesting writing style
Rating: 5
The method of material presentation made reading clear, understandable and interest as well as curiowity provoking.
Summary: A question biologists rarely ask any more
Rating: 3
Modern biologists rarely concern themselves with what life is. As Francois Jacob put it, "today we don't interrogate life in our laboratories", and Henri Atlan put it even more plainly: "Today a molecular biologist does not need to use the word 'life' for his work." Nonetheless, at the beginning of the twentieth century there was a lot of interest in defining life, with what now seem to be incredibly optimistic predictions of how long it would take to create life artificially. A little of this interest has survived until now, though Jacob and Atlan are right in regarding it as being far removed from the everyday preoccupations of practising biologists. In this interesting but demanding book, Evelyn Fox Keller traces the development from Stephane Leduc at the beginning of the twentieth century to the artificial life enthusiasts of today.
Leduc thought that the appearance of forms resembling plants produced by osmotic effects in concentrated colloidal mixtures of inorganic salts had something to tell us about the emergence of life. Although he did not claim that these forms were actually living, some of his supporters were less restrained, and even during his lifetime Leduc became completely marginalized. A different fate awaited his near contemporary d'Arcy Thompson, whose famous book On Growth and Form has retained its appeal up to the present day. Keller is probably right, however, when she writes "yet, for all its fame, I suspect that few people today actually read On Growth and Form, and fewer still know what to make of it". Certainly, few of his admirers appreciate how far removed was his thinking from the neo-darwinism that dominates modern biology.
Keller's careful analysis of Leduc's and Thompson's ideas in the earlier part of the book is not, unfortunately, matched by an equally thorough examination of their successors in theoretical biology. Although she devotes several pages to the career of Nicolas Rashevsky, for example, she barely mentions Rashevsky's ideas, concentrating almost entirely on the political aspects of his career, describing how his early success in establishing a school of theoretical biology in Chicago collapsed in 1954 when his funding evaporated. More serious still, Keller ignores Robert Rosen completely -- mentioning him only in the notes at the end of the book, and then not as a major thinker in his own right but simply as Rashevsky's former student and the writer of his obituary. Humberto Maturana and Francisco Varela, do not even rate the minimal recognition accorded to Rosen: their names are not mentioned, and neither is their theory of autopoiesis.
In the latter part of the book, therefore, Keller appears to have missed the opportunity to examine ideas of complexity and the importance of treating systems as systems rather than as no more than as collections of components. She takes modern "systems biology" (which is concerned more with complicatedness than with complexity) essentially at its practioners' own valuation; likewise with other trendy ideas like cellular automata, artificial life and so on.
Summary: Keller's Life and Times of Genetics
Rating: 5
Keller's book is a fascinating read about genetics today, but just as fascinating about the intellectual developments that preceded today's thinking. She appreciates the thrill of the chase, but also provides the longer view, showing how scientific explanations that were satisfying to the scientists of a given day have frequently turned out to have little bearing on subsequent science-as our museums, T. Kuhn and Keller herself show. And the explanatory nuggets that scientists mine, which put science at the head of society's power train, often turn into the dusty errata of ensuing decades for reasons connected with researcher's attitudes. (This seems to be a factor some ambitious scientists resent contemplating.) She tracks the inclination of researchers and thinkers to project intentions on the gene-an ingrained "agentic" factor. Particularly interesting is what happened when physicists (she's one herself) tried to apply their particular skills and world view on biology-it seems that the powerful, overall formulas of physics, so brilliant in particle analysis and thinking about the universe on a grand scale, simply don't reach down to the particular instances of biology (Turing's theoretical description of the development of Drosophilia may be highly elegant and efficient, but as it turns out the fly, like Frank Sinatra, prefers to do it its own way). Keller writes clearly and well about her subject-her book also gives a rundown of future directions for genetic research-but for me the fun is in Keller's tracing how the search for knowledge is shaped differently from era to era; Keller's book gives us a glimpse of the waters that knowledge swims in.
Summary: History, but no explaining
Rating: 2
I was rather disappointed in this book. Keller's view of 'explanation' is that it is relative to the needs of each particular culture and their historical time (p. 5). As such, she does not really critique or analyze the various historical concepts to any degree. Essentially, she presents what happened, and who did it, and how some things fell in or out of favor at a given time.
The result is that this book is essentially a narrative of approximately the last century of the history of biology. In that regard, it does succeed somewhat at attempting to condense the efforts of 100+ years of biology into about 300 pages. That is why I gave it two stars.
However, as Keller is a MIT philosopher of science and also trained in theoretical physics, I had expected more analytic depth, and some kind of "edge" - some thesis or thread or some other kind of thematic reason for her to be telling us all this history. Even on the most fundamental question of biology, "what is life?", Keller equivocates, calling it "a historical question, answerable only in terms of the categories that we as human actors choose to honor, and not in logical, scientific or technical terms." (p.294) Indeed, she does not even mention Schrodinger's 1943 lecture, "What is Life?"
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