Handbook on metals in clinical and analytical chemistry - ISBN:0824790944

Handbook on metals in clinical and analytical chemistry

Date: 14 April 2011, 19:25

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Although the documented use of metals in Iatrochemistry by Theophrast B6mbast von Hohenheim (called Paracelsus, 1493-1541) dates back to the first half of the 16tche ntury, the important role of metal ions for all kinds of biological systems-from microorganisms to humans-has only been recognized during this century. Different requirements must be fulfilletod understand the role of a metal ion in a biological system. At first the metal ion must be detected with high specificity and selectivity, and then its quantity must be determined with high accuracy, sometimes at a very low level, in different compartments of the body. However, the proof of the presence of a metal ion alone gives no or only little information about its beneficial or deleterious effects. In order to attribute observed phenomena to a distinct metal ion, it is necessary to understand its interactions with the constituents of the biological system, its uptake, metabolism, and excretion.

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