Targeted Therapies: Mechanisms of Resistance - ISBN:1607614774

Targeted Therapies: Mechanisms of Resistance

Date: 19 June 2011, 06:02

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Contents
1 Resistance to Targeted Therapies As a Result of Mutation(s) in the Target.......................................................................... 1
Alexis B. Cortot and Pasi A. Janne
2 The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.............................................................................. 33
Daniel Gioeli
3 Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.................................................................................... 55
Jason R. Neil and Forest M. White
4 Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications......................... 77
Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta, and Emanuel F. Petricoin III
5 Using Phosphoflow™ to Study Signaling Events of Subpopulations Resistant to Current Therapies..................................... 95
Omar D. Perez
6 Mathematical and Computational Models in Cancer............................ 113
Sudhir Chowbina, Kevin A. Janes, Shayn M. Peirce, and Jason A. Papin
7 Somatic Evolution of Acquired Drug Resistance in Cancer.................. 127
John W. Pepper
8 Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer.................................. 135
Edward Gunther
9 microRNA: A Potential Therapy Able to Target Multiple Cancer Pathways...................................................................... 155
Benjamin Kefas and Benjamin W. Purow
10 Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance............................................................................ 171
Yun Dai and Steven Grant
Index.................................................................................................................. 197

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