Peptides and Neurological Disease (Laboratory Techniques in Biochemistry and Molecular Biology) - ISBN:0444807330

Peptides and Neurological Disease (Laboratory Techniques in Biochemistry and Molecular Biology)

Date: 28 April 2011, 12:44

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During the last two decades there has been a dramatic increase in studies concerned
with the measurement of neurotransmitters in neurological and psychiatric illness. Much
of this interest stems from the pioneering studies of Horynkiewicz and colleagues of the
dopamine deficit in Parkinson’s disease and its amelioration with large doses of L-Dopa,
which rapidly led to the investigation of the chemical pathology of Alzheimer’s disease,
Huntington’s disease and schizophrenia. Outstanding in these studies were the observations
of Bird and lversen and the Perry’s of the GABA deficit in Huntington’s chorea,
and the discovery by several groups of the cholinergic deficit in Alzheimer’s disease...

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