Origin and evolution of viruses - ISBN:0122203607

Origin and evolution of viruses

Date: 14 April 2011, 12:25

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Viruses differ greatly in their molecular strategies of adaptation to the organisms they infect. RNA viruses utilize continuous genetic change as they explore sequence space to improve their fitness, and thereby to adapt to the changing environments of their hosts. Variation is intimately linked to their disease-causing potential. Paramount to the understanding of RNA viruses is the concept of quasispecies, first developed to describe the early replicons thought to be components of a primitive RNA world devoid of DNA or proteins. The first chapters of the book deal with theoretical concepts of self-organization, RNA-mediated catalysis and the adaptive exploration of sequence space by RNA replicons.

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