Neural Stem Cells for Brain and Spinal Cord Repair - ISBN:1588290034

Neural Stem Cells for Brain and Spinal Cord Repair

Date: 14 April 2011, 00:07

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The stem cell field has captured the imagination of the therapeutic community. Stem cells are defined as those cells that can give rise to a vast array of cell types (”pluripotency”) as well as to other stem cells (“self-renewal”). The most primordial stem cell is that obtained from the inner cell mass of the blastocyst; these are termed “embryonic stem cells” and can theoretically give rise to all of the cells of the developing organism. By a series of developmental steps, these embryonic stem cells are presumed to give rise to cells with similar stem-like qualities, but that come to populate the various emerging organs of the embryo and fetus. These cells, termed “tissue-resident” or “tissue-derived stem cells, retain stem-like features, but somehow have “learned” their address within the body. They are postulated to exist not only in the embryo and fetus where they participate in specific organogenesis, but to persist into adulthood, possibly to maintain homeostasis or to mediate selfrepair or regenerative processes.

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