Metabolic and Therapeutic Aspects of Amino Acids in ClinIcal Nutrition - ISBN:0849313821

Metabolic and Therapeutic Aspects of Amino Acids in ClinIcal Nutrition

Date: 13 April 2011, 17:11

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A review of the history of proteins and amino acids at the beginning of the twentieth century makes it apparent that the physiology of the protein was moving toward the physiology of amino acids. The recognition of individual amino acids had developed for over 100 years when Rose reported threonine in 1936. 1 Yet the chemical identification of individual amino acids involved an immense amount of time and skill, which usually required the isolation of a material that could be weighed. This situation underwent major changes in the 1940s and 1950s when new methodology changed the measurement of amino acids to rapid and automated procedures. Advances of the 1940s were associated with the stimulus of the wartime search for antibiotics such as gramicidin. During this period came the discovery that certain bacteria could be used quantitatively to measure the presence of specific amino acids. Fruton 2 has summarized the advances of this period.

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