Hydrolysis in Drug and Prodrug Metabolism - ISBN:390639025X

Hydrolysis in Drug and Prodrug Metabolism

Date: 13 April 2011, 17:13

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Most drugs and other xenobiotics (compounds foreign to an organism) are metabolized to inactive and excretable compounds by an uncounted arsenal of enzymes. Among these enzymes are the hydrolases reviewed in this book. Xenobiotics enter the organism via the intestine, lung, skin, and other barriers between the organism and its environment, at which sites they may already be biotransformed. Clearly, however, the major organ of drug metabolism is the liver. It is a major ‘filter’ between the gut and systemic circulation, pointing to the importance of dietary xenobiotics that have to be ‘detoxified’. Defense against the invasion of small lipid-soluble molecules in the diet and the air most probably has been the evolutionary force in the proliferation of this large number of enzymes of drug metabolism from genes that previously coded for enzymes involved in the metabolism of endogenous compounds such as fatty acids, sterols, bile acids, vitamins, etc.

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