Human Retrovirus Protocols: Virology and Molecular Biology - ISBN:1588294951

Human Retrovirus Protocols: Virology and Molecular Biology

Date: 13 April 2011, 02:42

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Retroviruses are a large and diverse family of enveloped, single-strand RNA viruses characterized by the unique replicative strategy that includes reverse transcription of the virion RNA into linear double-stranded DNA and the subsequent integration of this DNA into the genome of the cells. Human retroviruses are subdivided into three groups: oncoviruses, lentiviruses, and spumaviruses. Oncoviruses have been associated with a variety of cancers. The first human retrovirus, human T-lymphotropic virus type 1 (HTLV-1), was discovered in the late 1970s, and was shown to cause adult T-cell leukemia and chronic neurological conditions. A relative of HTLV-1, HTLV-II, has also been associated with human leukemias. The most significant disease resulting from human retrovirus infection is the acquired immunodeficiency syndrome (AIDS), which is caused by lentiviruses, human immunodeficiency viruses type 1 and type 2 (HIV-1 and HIV-2). Spumaviruses cause no known disease in humans and interest in this category is relatively recent.

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