Cyclooxygenases: Methods and Protocols - ISBN:1588299538

Cyclooxygenases: Methods and Protocols

Date: 15 April 2011, 04:08

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The nonsteroidal anti-inflammatory drugs (NSAIDs) consist of more than 40 compounds, which are the most widely used group of medicines worldwide for the treatment of inflammation, pain, fever, and for the prevention of thrombosis. It was through the pivotal work of the late Professor Sir John Vane in the early 1970s that it was realized that the mechanism of pharmacological and toxicological actions of these compounds depended on the inhibition of the catalytic activity of the cyclooxygenase (COX) enzyme resulting in the reduction of prostaglandin synthesis. After the discovery of the second isoform of COX, named COX-2 in the early 1990s, it became clear that the pharmacological actions of NSAIDs were due to the inhibition of COX-2, while the toxicological actions were due to inhibition of COX-1. Thus COX-1 became known as the “house-keeping” isoform involved in prostaglandin synthesis during physiological processes such as regulation of acid release in the stomach, while COX-2 as the inducible isoform involved in pathological processes such as inflammation, pain, fever, and cancer. Eventually, this led to the development of the first.

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