Chromosomal Alterations: Methods, Results and Importance in Human Health - ISBN:3540714138

Chromosomal Alterations: Methods, Results and Importance in Human Health

Date: 13 April 2011, 17:31

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This book deals mainly with chromosomal alterations which represent changes in the structure (chromosome mutations) or number (genome mutations) of chromosomes and with sister chromatid exchanges (SCE). Double-strand breaks (DSB) in DNA are the ultimate lesions for the formation of chromosome mutation and SCE evaluated in the light microscope. Typical chromosomal alterations are chromosomal aberrations (CA) and micronuclei (MN). SCE result from repair of lesions during S phase (“true” SCE), or from chromosome-type CA induced during G1 phase (“false” SCE). Numerical alterations of chromosomes are discussed with respect to their importance in clinical cytogenetics, to their ability to give rise to MN containing whole chromosomes and to their origin during divisions of CA containing cells.

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