Carbohydrate-Based Vaccines - ISBN:0841239835

Carbohydrate-Based Vaccines

Date: 14 April 2011, 17:09

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Given the increasing incidence of microbial resistance to antibiotics, the failure to adequately treat certain diseases such as parasite infections, the resurgences of some bacteria that were thought to be eradicated in developed countries, and the magnificent progress recently made in glycobiology, the time has come to better adequately (re)address the issue of prophylactic treatments through vaccination programs. There was a time when killed or attenuated bacteria or viruses constituted the first vaccine generation. A partial understanding of how the immune system handles carbohydrate antigens has been the causative event that triggered the use of bacterial components such as capsular polysaccharide as one of the structural elements against which our bodies could mount potent humoral immune responses. These purified antigens represented vaccines pf the second generation.

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