Date: 27 April 2011, 11:56
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Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource. TABLE OF CONTENTS Prologue: Philosophy of the Book Part I: Tools Chapter 1 Introduction to Part I Chapter 2 Elements of Combinatorial Logic Chapter 3 Kinetic Logic I: From Logical Structure to Behavior Chapter 4 Kinetic Logic II: The Conditions Determining the Choices Among Pathways Chapter 5 Inductive Use of Kinetic Logic Chapter 6 Elements of the Differential Description Chapter 7 Generalized Kinetic Logic Chapter 8 Generalized Logical vs. Differential Description Part II: Feedback Loops Chapter 9 Introduction to Part II Chapter 10 Simple Negative Feedback Loops Generate Homeostasis: Differential Description Chapter 11 Simple Negative Feedback Loops Generate Homeostasis: Logical Description Chapter 12 Simple Positive Feedback Loops Generate Differentiation: Differential Description Chapter 13 Simple Positive Feedback Loops Generate Multistationarity: Logical Description Chapter 14 How Can a Transient Signal Switch a Function on Permanently? Chapter 15 Many Steady States Chapter 16 Systems with Positive and Negative Feedback Loops Part III: Applications Chapter 17 Epigenetic Differences and Multiple Steady States Chapter 18 Logical Treatment of Diffusion Chapter 19 The SOS Response Chapter 20 Bacteriophage ? Chapter 21 Neuronal Networks Chapter 22 A Model Analysis of the Immune Response Chapter 23 On Determination and Differentiation Concluding Remarks Appendix 1 How to Find a Steady State Value By Iteration Appendix 2 Trajectories and Evolution Appendix 3 A Little More about Linear Stability Analysis Appendix 4 Asynchronous vs. Synchronous Description Index
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