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Apoptosis and Cancer Therapy
Apoptosis and Cancer Therapy
Date: 13 April 2011, 14:50

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Programmed cell death or apoptosis is a distinct, intrinsic cell death progam that occurs in various physiological situations during normal development and in the adult organism. Since tissue homeostasis critically depends on the balance between proliferation and cell death, an aberrant increase or decrease in apoptosis is observed in a variety of pathological conditions. Since the discovery of the basic biological phenomenon in the early seventies by Kerr and colleagues, an extraordinary progress has been made over the last decades in our understanding of the molecular pathways that regulate apoptosis. One of the most important advances in cancer research in recent years is the recognition that cells death by apoptosis is crucially involved in regulation of tumor formation and also critically determines treatment response.

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