Antitargets: Prediction and Prevention of Drug Side Effects - ISBN:3527318216

Antitargets: Prediction and Prevention of Drug Side Effects

Date: 22 April 2011, 08:25

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When the hammer hits your thumb in addition to, or instead of the nail - this clearly is an antitarget problem. In drug action and especially in drug-drug interactions, the situation is much more serious. There are numerous targets which should not be activated, induced, or inhibited by a drug. Adverse drug reactions (ADRs) are estimated to be one of the leading causes of morbidity and mortality in healthcare. Especially older patients receive up to 15 different medications, and evenmore, at the same time – no wonder that unfavorable drug-drug interactions happen, considering also the poor physical condition of such patients. In January 2000, the Institute of Medicine reported that in the US about 7000 deaths per year occur due to ADRs; the number may be even much larger, not to count the manyfold non-fatal side effects. In defining the term ‘‘antitarget’’ one runs into some problems. Let us start with terfenadine, a non-sedating H1-antihistaminic. In its clinical studies it was obviously safe, with only minor side effects. However, after its broad therapeutic use it turned out to produce fatal arrhythmias.

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