Annual Review of Immunology 2003 - ISBN:0824330218

Annual Review of Immunology 2003

Date: 09 April 2011, 14:57

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lthough the studies of genetic primary human immunodeficiency diseases were of great heuristic value, our understanding of the immune system was hindered by the fact that unseparated lymphocytes represent mixtures of complex populations of cells with different and at times opposing functions. They presented a confusing Tower of Babel sending diverse and often conflicting signals that were difficult to analyze. Monoclonal antibodies and the techniques to clone lymphocytes had not been developed.

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