It is common knowledge that otitis media is the most frequent diagnosis made by physicians who provide health care to infants and children. However, clinicians often confront older patients who develop this disease, which occurs in all age groups. It is estimated that over 20,000 adults have tympanostomy tubes inserted in their ears annually. Otitis media is a worldwide disease that not only has a substantial impact on patients and their families, but also is a burden on health care systems in both industrialized nations and developing countries. Thus, we now have Advanced Therapy in Otitis Media, which provides answers to clinical care questions from the most common problems to the relatively rare complications and sequelae of otitis media. This content is targeted at clinicians who face this disease daily, in their practice, in a variety of presentations. They include primary care physicians in the community and in tertiary care medical centers, including pediatricians, internists, family care practitioners, specialists in otolaryngology, immunology and allergy, and infectious diseases, and medical students and residents in training. Because the disease is universal, the information provided is directed toward clinicians around the world.